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Hyfé Raises $9 Million to Create Future Feedstocks for Biomanufacturing

• Investment • Press Release

SAN FRANCISCO, CA – June 22, 2023 Hyfé, a company transforming food processing wastewater into feedstocks for biomanufacturing and clean water, today announced an oversubscribed $9 million seed investment led by Synthesis Capital. Additional participating investors include The Engine, Refactor Capital, Supply Change Capital, Overwater Ventures, X Factor Ventures and Alumni Ventures. The company’s funding to date is $11 million, which includes an oversubscribed pre-seed round led by The Engine in April 2022. Hyfé will use the new capital to advance select commercial partnerships, double its employee headcount, and progress towards pilot scale technology demonstration. Rosie Wardle, co-founder and partner at Synthesis Capital, will also join the company’s Board of Directors.

Biomanufacturing offers a path to decarbonize key industrial sectors such as foods, fuels, materials, and chemicals, and is forecasted to mitigate at least 3 GT of carbon emissions annually by 2030. However, it’s difficult for the sector to compete with incumbent processes that depend on fossil resources, animal agriculture, and deforestation. Cost and supply of sugar feedstocks used to power bioprocesses is a major obstacle towards achieving price parity and the glucose needs of the bioeconomy are forecasted to outpace supply over the next 10-20 years. It is critical for the feedstocks that will power that growth to come from underutilized waste carbon streams that are cost effective, non-competitive with food, and avoid disruption of agricultural systems.

“Biomanufacturing has the potential to solve some of the most pressing challenges facing humanity, but first it needs to be made economically viable,” said Michelle Ruiz, co-founder and CEO of Hyfé. “We are building a solution that addresses a fundamental bottleneck for the bioeconomy just as it’s reaching an inflection point. This historic moment is as pivotal as the invention of the steam engine, the age of science and mass production, and the rise of digital technology.”

While other companies are working to convert solid food and agricultural waste into fermentation feedstocks, Hyfé is leveraging their extensive experience in wastewater treatment and fermentation-enabled waste valorization to develop feedstocks from food processing wastewater, an abundant and untapped source of carbon, enabling:

  • Food and beverage manufacturers to dramatically reduce wastewater treatment costs and increase water reuse, thereby improving water resiliency and overall operating expenses
  • Biomanufacturers to access more sustainable, affordable feedstocks, which account for the majority of fermentation operating expenses and are vulnerable to supply chain disruptions
  • Our planet to benefit from increasingly carbon negative manufacturing all along the supply chain, starting with diverting organic loads entering traditional wastewater treatment – a process that accounts for up to 1.5% of global greenhouse gas emissions in the form of methane, carbon dioxide, nitrogen oxides and sulfur oxides.

Hyfé’s technology processes nutrient building blocks from wastewater into easy-to-metabolize feedstocks for bioprocesses. They are engineering solutions to key bottlenecks in alternative feedstock development: compositional variability, availability, and lack of data.

“The future bioeconomy will be worth at least $4 trillion, and up to $30 trillion globally. We have a timely opportunity to propel this growth through the development of cost-efficient and sustainable feedstocks,” said Rosie Wardle, co-founder and partner at Synthesis Capital. “We’re thrilled to support Hyfé, a leader in the biomanufacturing revolution, in their next phase of growth, applying their technology to power the development of more sustainable products across sectors through bioproduction. This is something the world desperately needs to reduce our dependence on fossil fuels, revitalize the manufacturing sector, strengthen our supply chains, and improve our health and environment.”

Food companies that generate wastewater and biomanufacturing companies that use sugar-based feedstocks can contact [email protected] to learn more about the company and its partnership opportunities.

About Hyfé

Hyfé creates the future feedstocks of biomanufacturing from nutrients lost in trillions of gallons of food processing wastewater. Their technology enables water reuse and lowers the cost of wastewater and water management at food manufacturing facilities while enabling abundant and underutilized waste streams to fuel the growth of the bioeconomy. The company was founded by ExxonMobil and LanzaTech engineers in 2021 and is backed by investors like Synthesis Capital, The Engine, Refactor Capital, Supply Change Capital, among others. The company secured a grant from Chain Reaction Innovations, the entrepreneurship program at Argonne National laboratory supported by the U.S. Department of Energy. For more information, visit or follow Hyfé on LinkedIn.

About Synthesis Capital

Synthesis Capital is a global food technology and alternative protein investor with operations in the UK, US, and Guernsey. The firm’s founding team has been investing in the sector’s leading companies since its emergence in 2014, developing deep expertise across the core technologies that will comprise our future food system. With proprietary access to both the leading established players in the sector, and the next wave of high potential companies transforming the food system, Synthesis Capital Fund investments to date include Upside Foods, Perfect Day, Redefine Meat, Culture Biosciences, and Arkeon Biotechnologies. For more information, visit

Media Contact

Corey Patz

[email protected]

For more, please see full press release on PR Newswire.

by Rosie Wardle, Co-Founder and Partner